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Iran as the most populated country in the Middle East with a population of about ~82 million is the 18th largest population in the world. Iran is also a developing country with a high rate of consanguineous marriages, and thereby has a significant number of patients affected with some rare bleeding disorders. Recently, the Ministry of Health in Iran has established a national registry of bleeding disorders in the country. Although this program is still in the early stage, it can be helpful in better understanding and management of patients with RDBs.

1.Hemophilia

Based on population, Iran has one of the highest global incidences in hemophilia. A survey by World Federation of Hemophilia (WFH) in 2014, in 107 countries, identified 176 211 people with hemophilia (A and B), 140 313 of whom had HA. According to this survey, Iran, with 5369 patients, has the ninth largest hemophilia population, in 2014, 4438 had HA and 931 had HB.

hematology in Iran

2.von Willebrand disease

Based on the Iranian Hemophilia Society (HIS) report, the total number of patients with hemostatic disorders in Iran is 10,944 (a prevalence of 131 per million), while the number of registered patients with VWD is 1,617 and 1,516 according to the IHS and annual global survey report of World Federation of Hemophilia (WFH), respectively (a prevalence of ~19 per million). Due to high rate of consanguineous marriage and autosomal recessive inheritance pattern of type 3, the prevalence of type 3 is around 4 per million in Iran, which overshadows that of Western European countries with a reported prevalence of ~0.45 per million.

hematology in Iran

3.Factor XIII Deficiency

Owing to a high rate of consanguineous marriages, Iran has an extremely high prevalence of FXIIID, approximately 12-fold higher than the overall frequency in the rest of the world, with southeastern Iran showing the highest prevalence of FXIIID worldwide.

hematology in MENA in different provinces of Iran

4.Afibrinogenemia

5.Dysfibrinogenemia

6.Factor II deficiency

7.Factor V deficiency

8.Factor V+VIII deficiency

9.Factor VII deficiency

10.Factor X deficiency

11.Factor XI deficiency

12.Factor XII deficiency

13.II + VII + IX + X deficiency

14.Plasminogen deficiency

15.VII + XI deficiency

16.Acquired Haemophilia